Presence of PI-rich vesicles is required for the PLC ζ activation according to mathematical modeling
Introduction
Essential Role of Sperm-Specific PLC-Zeta in Egg Activation and Male Factor Infertility: An Update
A. Saleh, J. Kashir, A. Thanassoulas, B. Safieh-Garabedian, F. Lai, M. Nomikos
Frontiers in Cell and Developmental Biology. 2020, 8, None
Broad, ectopic expression of the sperm protein PLCZ1 induces parthenogenesis and ovarian tumours in mice
N. Yoshida, M. Amanai, T. Fukui, E. Kajikawa, M. Brahmajosyula, A. Iwahori, Y. Nakano, S. Shoji, J. Diebold, H. Hessel, R. Huss, A. Perry
Development. 2007, 134, 3941-3952
Phospholipase C zeta and calcium oscillations at fertilisation: The evidence, applications, and further questions
J. Kashir, M. Nomikos, F. Lai
Advances in Biological Regulation. 2018, 67, 148-162
Broad, ectopic expression of the sperm protein PLCZ1 induces parthenogenesis and ovarian tumours in mice
N. Yoshida, M. Amanai, T. Fukui, E. Kajikawa, M. Brahmajosyula, A. Iwahori, Y. Nakano, S. Shoji, J. Diebold, H. Hessel, R. Huss, A. Perry
Development. 2007, 134, 3941-3952
PLCζ is the physiological trigger of the Ca2+ oscillations that induce embryogenesis in mammals but offspring can be conceived in its absence.
Hachem A, Godwin J, Ruas M, Lee HC, Buitrago MF, Ardestani G, et al.
Development. 2017, None, None
PLCζ is the physiological trigger of the Ca2+ oscillations that induce embryogenesis in mammals but offspring can be conceived in its absence.
Hachem A, Godwin J, Ruas M, Lee HC, Buitrago MF, Ardestani G, et al.
Development. 2017, None, None
Phospholipase C zeta and calcium oscillations at fertilisation: The evidence, applications, and further questions
J. Kashir, M. Nomikos, F. Lai
Advances in Biological Regulation. 2018, 67, 148-162
PLCζ is the physiological trigger of the Ca2+ oscillations that induce embryogenesis in mammals but offspring can be conceived in its absence.
Hachem A, Godwin J, Ruas M, Lee HC, Buitrago MF, Ardestani G, et al.
Development. 2017, None, None
Divergent effect of mammalian PLCζ in generating Ca2+ oscillations in somatic cells compared with eggs
S. Phillips, Y. Yu, A. Rossbach, M. Nomikos, V. Vassilakopoulou, E. Livaniou, B. Cumbes, F. Lai, C. George, K. Swann
Biochemical Journal. 2011, 438, 545-553
PLCζ is the physiological trigger of the Ca2+ oscillations that induce embryogenesis in mammals but offspring can be conceived in its absence.
Hachem A, Godwin J, Ruas M, Lee HC, Buitrago MF, Ardestani G, et al.
Development. 2017, None, None
Starting a new life: Sperm PLC-zeta mobilizes the Ca2+ signal that induces egg activation and embryo development
M. Nomikos, K. Swann, F. Lai
BioEssays. 2012, 34, 126-134
A single-pool model for intracellular calcium oscillations and waves in the Xenopus laevis oocyte
A. Atri, J. Amundson, D. Clapham, J. Sneyd
Biophysical Journal. 1993, 65, 1727-1739
Materials and methods
Computational model construction and integration
To study the PLCζ activity in mammalian eggs, a computer model was developed. First, the ordinary differential equations were constructed based on laws of chemical kinetics (either mass action law, Henry-Michaelis-Menten kinetics, or Hill functions). Kinetic equation parameters were either taken from the literature or estimated based on existing experimental data. The final model consisted of 18 equations with two unknown parameters. The model was solved using the LSODA method.
Results and discussion
Mathematical model of PLCζ activity
Divergent effect of mammalian PLCζ in generating Ca2+ oscillations in somatic cells compared with eggs
S. Phillips, Y. Yu, A. Rossbach, M. Nomikos, V. Vassilakopoulou, E. Livaniou, B. Cumbes, F. Lai, C. George, K. Swann
Biochemical Journal. 2011, 438, 545-553
A Model for the Acrosome Reaction in Mammalian Sperm
J. Simons, L. Fauci
Bulletin of Mathematical Biology. 2018, 80, 2481-2501
Divergent effect of mammalian PLCζ in generating Ca2+ oscillations in somatic cells compared with eggs
S. Phillips, Y. Yu, A. Rossbach, M. Nomikos, V. Vassilakopoulou, E. Livaniou, B. Cumbes, F. Lai, C. George, K. Swann
Biochemical Journal. 2011, 438, 545-553
A Model for the Acrosome Reaction in Mammalian Sperm
J. Simons, L. Fauci
Bulletin of Mathematical Biology. 2018, 80, 2481-2501
PLCζ is the physiological trigger of the Ca2+ oscillations that induce embryogenesis in mammals but offspring can be conceived in its absence.
Hachem A, Godwin J, Ruas M, Lee HC, Buitrago MF, Ardestani G, et al.
Development. 2017, None, None
A Model for the Acrosome Reaction in Mammalian Sperm
J. Simons, L. Fauci
Bulletin of Mathematical Biology. 2018, 80, 2481-2501
Human PLC exhibits superior fertilization potency over mouse PLC in triggering the Ca2+ oscillations required for mammalian oocyte activation
M. Nomikos, M. Theodoridou, K. Elgmati, D. Parthimos, B. Calver, L. Buntwal, G. Nounesis, K. Swann, F. Lai
Molecular Human Reproduction. 2014, 20, 489-498
Recombinant Phospholipase Cζ Has High Ca2+ Sensitivity and Induces Ca2+ Oscillations in Mouse Eggs
Z. Kouchi, K. Fukami, T. Shikano, S. Oda, Y. Nakamura, T. Takenawa, S. Miyazaki
Journal of Biological Chemistry. 2004, 279, 10408-10412
Human PLC exhibits superior fertilization potency over mouse PLC in triggering the Ca2+ oscillations required for mammalian oocyte activation
M. Nomikos, M. Theodoridou, K. Elgmati, D. Parthimos, B. Calver, L. Buntwal, G. Nounesis, K. Swann, F. Lai
Molecular Human Reproduction. 2014, 20, 489-498
The Role of EF-hand Domains and C2 Domain in Regulation of Enzymatic Activity of Phospholipase Cζ
Z. Kouchi, T. Shikano, Y. Nakamura, H. Shirakawa, K. Fukami, S. Miyazaki
Journal of Biological Chemistry. 2005, 280, 21015-21021
Hill approximation of PLCζ activity
Recombinant Phospholipase Cζ Has High Ca2+ Sensitivity and Induces Ca2+ Oscillations in Mouse Eggs
Z. Kouchi, K. Fukami, T. Shikano, S. Oda, Y. Nakamura, T. Takenawa, S. Miyazaki
Journal of Biological Chemistry. 2004, 279, 10408-10412
Role of Phospholipase C-ζ Domains in Ca2+-dependent Phosphatidylinositol 4,5-Bisphosphate Hydrolysis and Cytoplasmic Ca2+ Oscillations
M. Nomikos, L. Blayney, M. Larman, K. Campbell, A. Rossbach, C. Saunders, K. Swann, F. Lai
Journal of Biological Chemistry. 2005, 280, 31011-31018
Recombinant Phospholipase Cζ Has High Ca2+ Sensitivity and Induces Ca2+ Oscillations in Mouse Eggs
Z. Kouchi, K. Fukami, T. Shikano, S. Oda, Y. Nakamura, T. Takenawa, S. Miyazaki
Journal of Biological Chemistry. 2004, 279, 10408-10412
The complete model of phospholipase C activity in mammalian spermatozoa and egg cells
A single-pool inositol 1,4,5-trisphosphate-receptor-based model for agonist-stimulated oscillations in Ca2+ concentration.
G. De Young, J. Keizer
Proceedings of the National Academy of Sciences. 1992, 89, 9895-9899
Are there inositol 1,4,5-triphosphate (IP3) receptors in human sperm?
Y. Kuroda, S. Kaneko, Y. Yoshimura, S. Nozawa, K. Mikoshiba
Life Sciences. 1999, 65, 135-143
Comparison of gating dynamics of different IP3R channels with immune algorithm searching for channel parameter distributions
X. Cai, X. Li, H. Qi, F. Wei, J. Chen, J. Shuai
Physical Biology. 2016, 13, 056005
Broad, ectopic expression of the sperm protein PLCZ1 induces parthenogenesis and ovarian tumours in mice
N. Yoshida, M. Amanai, T. Fukui, E. Kajikawa, M. Brahmajosyula, A. Iwahori, Y. Nakano, S. Shoji, J. Diebold, H. Hessel, R. Huss, A. Perry
Development. 2007, 134, 3941-3952
Are there inositol 1,4,5-triphosphate (IP3) receptors in human sperm?
Y. Kuroda, S. Kaneko, Y. Yoshimura, S. Nozawa, K. Mikoshiba
Life Sciences. 1999, 65, 135-143
Conclusions
References of this article:
Essential Role of Sperm-Specific PLC-Zeta in Egg Activation and Male Factor Infertility: An Update
A. Saleh, J. Kashir, A. Thanassoulas, B. Safieh-Garabedian, F. Lai, M. Nomikos
Frontiers in Cell and Developmental Biology. 2020, 8,
Broad, ectopic expression of the sperm protein PLCZ1 induces parthenogenesis and ovarian tumours in mice
N. Yoshida, M. Amanai, T. Fukui, E. Kajikawa, M. Brahmajosyula, A. Iwahori, Y. Nakano, S. Shoji, J. Diebold, H. Hessel, R. Huss, A. Perry
Development. 2007, 134, 3941-3952
Phospholipase C zeta and calcium oscillations at fertilisation: The evidence, applications, and further questions
J. Kashir, M. Nomikos, F. Lai
Advances in Biological Regulation. 2018, 67, 148-162
PLCζ is the physiological trigger of the Ca2+ oscillations that induce embryogenesis in mammals but offspring can be conceived in its absence.
Hachem A, Godwin J, Ruas M, Lee HC, Buitrago MF, Ardestani G, et al.
Development. 2017, ,
Divergent effect of mammalian PLCζ in generating Ca2+ oscillations in somatic cells compared with eggs
S. Phillips, Y. Yu, A. Rossbach, M. Nomikos, V. Vassilakopoulou, E. Livaniou, B. Cumbes, F. Lai, C. George, K. Swann
Biochemical Journal. 2011, 438, 545-553
Starting a new life: Sperm PLC-zeta mobilizes the Ca2+ signal that induces egg activation and embryo development
M. Nomikos, K. Swann, F. Lai
BioEssays. 2012, 34, 126-134
A single-pool model for intracellular calcium oscillations and waves in the Xenopus laevis oocyte
A. Atri, J. Amundson, D. Clapham, J. Sneyd
Biophysical Journal. 1993, 65, 1727-1739
A Model for the Acrosome Reaction in Mammalian Sperm
J. Simons, L. Fauci
Bulletin of Mathematical Biology. 2018, 80, 2481-2501
Human PLC exhibits superior fertilization potency over mouse PLC in triggering the Ca2+ oscillations required for mammalian oocyte activation
M. Nomikos, M. Theodoridou, K. Elgmati, D. Parthimos, B. Calver, L. Buntwal, G. Nounesis, K. Swann, F. Lai
Molecular Human Reproduction. 2014, 20, 489-498
Recombinant Phospholipase Cζ Has High Ca2+ Sensitivity and Induces Ca2+ Oscillations in Mouse Eggs
Z. Kouchi, K. Fukami, T. Shikano, S. Oda, Y. Nakamura, T. Takenawa, S. Miyazaki
Journal of Biological Chemistry. 2004, 279, 10408-10412
Role of Phospholipase C-ζ Domains in Ca2+-dependent Phosphatidylinositol 4,5-Bisphosphate Hydrolysis and Cytoplasmic Ca2+ Oscillations
M. Nomikos, L. Blayney, M. Larman, K. Campbell, A. Rossbach, C. Saunders, K. Swann, F. Lai
Journal of Biological Chemistry. 2005, 280, 31011-31018
The Role of EF-hand Domains and C2 Domain in Regulation of Enzymatic Activity of Phospholipase Cζ
Z. Kouchi, T. Shikano, Y. Nakamura, H. Shirakawa, K. Fukami, S. Miyazaki
Journal of Biological Chemistry. 2005, 280, 21015-21021
A single-pool inositol 1,4,5-trisphosphate-receptor-based model for agonist-stimulated oscillations in Ca2+ concentration.
G. De Young, J. Keizer
Proceedings of the National Academy of Sciences. 1992, 89, 9895-9899
Are there inositol 1,4,5-triphosphate (IP3) receptors in human sperm?
Y. Kuroda, S. Kaneko, Y. Yoshimura, S. Nozawa, K. Mikoshiba
Life Sciences. 1999, 65, 135-143
Comparison of gating dynamics of different IP3R channels with immune algorithm searching for channel parameter distributions
X. Cai, X. Li, H. Qi, F. Wei, J. Chen, J. Shuai
Physical Biology. 2016, 13, 056005
Calcium oscillations in mammalian eggs triggered by a soluble sperm protein
J. Parrington, K. Swann, V. Shevchenko, A. Sesay, F. Lai
Nature. 1996, 379, 364-368