Русский 
English Mechanical equilibrium of the cell nucleus and its potential role in regulation of chromatin structure
Biological functioning of living cells frequently relies on sophisticated cooperation between multiple cellular subsystems that must coexist with each other in a tight and highly crowded cellular space. As a result, the problem of space allocation to each of the cell components plays an important role in intracellular organization. Yet, there is still no full understanding of molecular mechanisms responsible for size regulation of the most of cellular organelles, including even the major ones, such as the cell nucleus. Moreover, despite recent discoveries of the central role of the nucleus geometry in shaping the cell response to environmental cues, molecular mechanisms underlying it remain unclear. To find answers to these questions, we have developed a general theoretical framework aimed at description of DNA packaging in nuclei of living cells, which was used to identify the major molecular processes accountable for the control of the cell nucleus size. Furthermore, the model showed the existence of a previously unknown link between the cell nucleus size and stability of nucleosomes, providing new insights into the potential role of nuclear organization in shaping the cell response to environmental cues.