English

Modelling of blood clotting in aneurysm

Aneurysms of saccular shape are usually associated with a slow, almost stagnant blood flow, as well as a consequent emergence of blood clots. Despite the practical importance, there is a lack of computational models that could combine platelet aggregation, precise biorheology and blood plasma coagulation into one efficient framework. In the present study we address both physical and biochemical effects during the thrombosis in aneurysms and blood recirculation zones. We use continuum description of the system and partial differential equation-based model that accounts for fluid dynamics, platelet transport, adhesion and aggregation, and biochemical cascades of plasma coagulation. The numerical simulations indicate an important role of RBCs in spatial propagation and temporal dynamics of the aneurysmal thrombus growth.