Biological systems at the supracellular level: hemostasis, immunity and neurobiology

Synergism between Anticoagulation and Phototherapy to Prevent the Thrombotic Complications

University of Science and Technology of China, Hefei, Anhui, 230026, China

State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, China

Find this author on Google Scholar

Cancer patients face risks of a broad range of thromboembolic complications, which threaten their lives. Some procoagulant substances, secreted by cancer cells, diffuse into bloodstream and lead to the hypercoagulable state of cancer patients. What’s more, the tumor hypoxia also can increase the thrombosis risks due to the down-regulation of S protein, an inhibitor of IXa factor. Besides, the traditional cancer treatment has been proved to increase the probability of venous thrombosis (VTE), such as surgery, chemotherapy and radiotherapy, which induces the vascular injuries and activates the coagulation pathway. Chemotherapy also can lead to the hypercoagulability through other mechanisms, such as reduction of natural coagulation inhibitors such as C protein, S protein and antithrombin III and activation to platelets. Therefore, appropriate clinical anticoagulant intervention is suggested in cancer patients.