English

Grigory Vasilev

Cellular automaton modelling of platelet aggregation

Platelet aggregation plays an important role in hemostasis, as it prevents blood loss upon vessel wall disruption. Computational modelling is one of the useful approaches to study this system.  The use of a cellular automaton as a model makes it possible both to study the dynamics of individual aggregates and to investigate the behaviour of the system as a whole. The aim of this research is to study platelet aggregation using a model based on a cellular automaton. As a result, a model of platelet aggregation in the basic approximation and with flow condition was constructed. It was shown that under flow conditions, the most number of the aggregates are dimers and trimers, whereas aggregates of large sizes are much less presented.

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#platelet aggregation#mathematical modeling#cellular automaton