English

Platelet functional responses and signalling: the molecular relationship. Part 2: receptors.

Received
September 27, 2021
Accepted
September 30, 2021
Published
September 30, 2021
Abstract

Small, non-nuclear cells, platelets, are primarily designed to form aggregates when blood vessels are damaged, stopping bleeding. To perform this function, platelets can implement several functional responses induced by various agonists and coordinated by a complex network of intracellular signaling triggered by a dozen of different receptors. This review, the second in a series, describes the known intracellular signaling pathways induced by platelet receptors in response to canonical and rare agonists. Particular focus will be on interaction points and “synergy” of platelet activation pathways and intermediate or “secondary” activation mediators that transmit a signal to functional manifestations.


2 782
article views
0
times cited
0
comments
pdf