English
Systems Biology and Systems Physiology 2022: Intracellular signaling and regulation of metabolism
Published
August 15, 2021

"Systems Biology and Systems Physiology 2022: Intracellular signaling and regulation of metabolism" is devoted to the studies of regulation of the functioning of living systems at all levels of organization - from subcellular to organismal, as well as discussion of experimental and theoretical approaches to the study of living systems

The ratio of Tpm α- and β-chains in the thin filament affects the actin-myosin interaction

#myosin#actin
595

Elevated shear rate is not specific to arterial thrombosis, but also relevant to hemostasis

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#murine models#hemostasis#thrombosis#thrombus formation#rodent models
608

A possible mechanism of ligand-receptor binding of short peptides to NaV1.8 channels: a novel approach to development of safe and effective analgesics

#patch-clamp#ion channel#ligand-receptor binding#neuron
584

The Tip of a Growing Microtubule and its Implications for Polymer Dynamics

#microtubules#tubulin#electron tomography#Brownian dynamics
596

Microgravity-induced bone loss: lessons learned from systematic reviews and meta-analysis

#bones#microgravity#meta-analysis#systematic review
560

Новый взгляд на контракцию (ретракцию) сгустков крови и тромбов

#thrombosis#contraction#thrombolysis
598

A mechanistic model for thromboelastography

#thromboelastography#mathematical modeling#hemostasis
668

Corticotropin-releasing factor (CRF) as a mediator of pain response to stressor: involvement of CRF receptors of subtype 2, opioid receptors and glucocorticoid receptors in CRF-induced analgesic effect in rats

#stress#glucocorticoid receptors#opioid receptors#analgesia
548

Mechanical equilibrium of the cell nucleus and its potential role in regulation of chromatin structure

#DNA packaging#nucleus#computational modeling
632

Mechanics of cell interaction, numerical modelling

#numerical modelling#cell interaction#biophysics
520

Reimagining the interaction between stress-induced glucocorticoids and gastric ulceration: the importance of a methodological approach

#stress#glucocorticoid receptors#rodent models
543

Structure of super-relaxed myosin heads in relaxed muscle

#myosin#cryo-electron microscopy#mathematical modeling#muscle contraction
572

Влияние гепарина на формирование и заживление язв желудка у крыс

#heparin#rodent models#inflammation
586

Role of tropomyosin dynamics in regulation of cardiac muscle in health and disease

#tropomyosin#muscle contraction#mathematical modeling
591

Oxidation-induced modifications of the blood coagulation factor XIII (FXIII) at the different stages of its activation identified by mass spectrometry

#coagulation#FXIII#mass spectrometry
569

How does viscosity help (!) the dynamics of spatial self-organization of molecular and supramolecular structures?

#macromolecular complexes#protein conformation#molecular mechanics
494

Лиганды PI3-киназы LY294002, LY303511 и PI828 блокируют сопряжение 5-HT2C рецептора с мобилизацией Ca2+ независимым от PI3-киназы образом

#intracellular signaling#phosphoinositides#low-molecular inhibitors
537

AED Peptide stimulates human stem cell differentiation into dermal fibroblasts

#fibroblasts#immunoflurescence microscopy#stem cells
603

KE and KED peptides regulate PARP and SIRT gene expression during replicative and stationary human mesenchymal stem cells ageing

#stem cells#gene expression#ageing
493

Euler arches and Duffing oscillators a few nanometers in size

#numerical modelling#molecular motors#forces#molecular dynamics
558

Platelet hemostasis reactions are tightly regulated by temperature

#hemostasis#platelets#platelet intracellular signaling
534

Experimental anticancer compound TIC10 induces transformation of BT474 human breast cancer cells to stable stress-state

#cancer#fluorescent microscopy#chemotherapy
654

Mechanisms of microtubule dynamic instability examined with Monte-Carlo simulations and in vitro reconstitution experiments

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#microtubules#numerical modelling#tubulin
507

Permitted and restricted steps of human kinetochore assembly in mitotic cell extracts

#mitosis#kinetochore#microtubules
510

Processes in photosynthetic membrane as an object of systems biology

#photosynthesis#membrane#mathematical modeling
570

In silico modelling of hemostatic response: challenges and perspectives

#hemostasis#computational modeling#thrombus formation#systematic review
651

Novel genetically encoded tools for compartment-specific manipulation of NADH/NAD+ and NADPH/NADP+ ratios in living cells

#genetic tools#redox metabolism#electron transport chain
577

Application of machine learning technologies in a non-invasive sensor system for diagnostics of a human functional state

#machine learning technologies#non-invasive diagnostics
604

KED peptide prevents synaptic contacts elimination of hippocampus neurons in an in vivo Alzheimer's disease model

#neuron#Alzheimer's disease#murine models#drug development
533

Calcium oscillations and autowaves in cells

#calcium signaling#autowaves#fluorescent microscopy#neuron
603

Thermodynamic and structural characteristics of cryoprotective media for cryopreservation of cells

#cryoconservation#spermatozoa#cell preservation
572

Numerical and qualitative investigation of the mathematical model of blood coagulation with membrane reactions

#mathematical modeling#coagulation#membrane reactions
581

Mathematical modeling of the RBC-bioreactors

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#mathematical modeling#red blood cells#drug-delivery
656

The role of single nucleotide polymorphisms (SNPs) within genes of platelet glycoprotein receptors and blood-coagulation factors II, V and XIII on coagulation and embolic risk in patients with infective endocarditis

#coagulation#single nucleotide polymorphisms#infective endocarditis#platelets#hemostasis
525

Melatonin effect on oxidative stress dynamics and DNA fragmentation in human spermatozoa

#oxidative stress#spermatozoa#hormones
626

Reversible aggregation and deformation of RBC as determining factors of blood fluidity control

#red blood cells#blood fluidity#RBC aggregometry#fibrinogen
611

Development of an automatic device for creating drug-loaded erythrocytes

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#drug-delivery#red blood cells#L-asparaginase
610

Oxidative modification of fibrinogen molecules: structural and functional aspects

#blood plasma coagulation#oxidative stress#HPLC#fibrinogen
559

Design of potential anti-aggregatory agents and their influence on human platelets activation

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#platelet activation#aggregometry#mass spectrometry#NMR spectroscopy#low-molecular inhibitors#anti-platelet drugs
577

Molecular dynamic model of NDC80 complex interaction with a microtubule

#molecular dynamics#microtubules#kinetochore
515

Virtual cell and theory of metabolic control

#glycolysis#mathematical modeling#metabolism#metabolomics
512

Quantum docking

#docking#force fields#computational modeling
609

Development of a track-etched membrane based method of the isolation of CTCs

#circulating tumor cells#cell culture#breast cancer#cytology
509

Mathematical modeling of hemodynamics in the left atrium during atrial fibrillation

#thrombosis#mathematical modeling
578

Overcoming kinase inhibitor resistance and oncogenic RAS signaling

#cancer#kinase#drug development
546

Construction of self-adaptive biomaterials surface with high blood compatibility

#self-adaptive#extracellular matrix#vascular implants#blood compatibility
563

The influence of blood clotting on pulmonary circulation

#mathematical modeling#thrombosis#pulmonary
594

Modelling of blood clotting in aneurysm

#mathematical modeling#coagulation#thrombosis#aneurysm
564

Simulation of the coagulation system: Tool or Toy ?

#hemostasis#mathematical modeling
572

Spatial effects in the complement system

#immunity#complement system#mathematical modeling
614

Synergism between Anticoagulation and Phototherapy to Prevent the Thrombotic Complications

#coagulation#photobiology
590